This course will introduce Computer-aided manufacturing (CAM) and applications extending the Computer Numerical Control (CNC) integrated machine tool application. A review of CNC and machining operations will be conducted first and followed by an ISO Numerical Control (NC) codes format introduction and a complete NC program interpretation and hands-on edit/writing practices. Shop floor operation will follow after the familiarity of an interactive 3D machine tool (I3DMT) software system. A worry-free last-mile integration application scenario will be introduced and practiced for online collision-free operation through an asynchronous collision detection algorithm. Talent students will be cultivated for online digital reality smart machine tools and the manufacturing industry. Systematic thinking and solutions with the innovative digital reality could be learned by the students.